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 in 
https://doi.org/10.3310/nihropenres.14059.2
Study Protocol metrics
Revised
Randomised controlled effectiveness study (RCT) of isometric exercise (IE) in adults with stage 1 and 2 hypertension – ISOFITTER study
[version 2; peer review: 1 approved, 1 approved with reservations]
Melanie Rees-Roberts, Ellie Santer, Rachel Borthwick, Timothy Doulton, Pauline A Swift, Tracy Pellatt-Higgins, Katerina Gousia, Douglas MacInnes, Alan West, John Darby, Anusree Biswas, Caroline Cowley, Christoher K Farmer, Jonathan Wiles
Peer Reviewers Giuseppe Caminiti; Heriviyatno J Siagian
  • Funders
  • National Institute for Health Research Applied Research Collaboration Kent Surrey Sussex
  • National Institute for Health and Care Research
  • Alan Squirrell Artificial Kidney Unit Trust
LATEST VERSION PUBLISHED 11 Dec 2025
https://doi.org/10.3310/nihropenres.13674.2
Research Article metrics
Revised
Unmet diagnostic needs in cystic fibrosis infections and exacerbations: focus groups to inform target product profiles (TPPs)
[version 2; peer review: 2 approved, 1 approved with reservations]
Nicola Howe, Constance Takawira, Raasti Naseem, Kile Green
Peer Reviewers Freddy Frost; Elizabeth B. Burgener; Morven Brown
  • Funders
  • NIHR
  • LifeArc
LATEST VERSION PUBLISHED 02 Dec 2025
https://doi.org/10.3310/nihropenres.14097.2
Study Protocol metrics
Revised
BronchStop Study Protocol, Season 2
[version 2; peer review: 3 approved]
Shaun O'Hagan, Steve Cunningham, Simon B Drysdale, Helen E Groves, Samantha Hunt, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Chengetai D Mpamhanga, Thomas Waterfield, Thomas C Williams, Robin Marlow, Damian Roland
Peer Reviewers Jonne Terstappen; Christine Blauvelt; Allen Nazareno
  • Funder
  • National Institute for Health and Care Research Health Protection Research Unit in Respiratory Infections
LATEST VERSION PUBLISHED 02 Dec 2025
https://doi.org/10.3310/nihropenres.14022.3
Research Article metrics
Revised
Gaining insights into a funding portfolio through publication tracking
[version 3; peer review: 1 approved, 2 approved with reservations]
Reetika Suri-Ogilvie, Sandra Hicks, Dominique Capostagno, Ashley Banks, Elena Ahmed, Kelly Makarona
Peer Reviewers Erik Canton; Josie Coburn; Shaoxiong Brian Xu
LATEST VERSION PUBLISHED 01 Dec 2025
https://doi.org/10.3310/nihropenres.13980.2
Systematic Review metrics
Revised
The effects of sunlight exposure on mortality: a systematic review of epidemiological studies
[version 2; peer review: 4 approved with reservations, 2 not approved]
Thomas Parkhouse, Francesca Spiga, Lesley E Rhodes, Sarah Dawson, Katie E Webster, Deborah M Caldwell, Julian P T Higgins
Peer Reviewers Maria Teresa Brito, Andrew Stevenson, Jiayue Gu and Richard Weller; Rasha Shraim; Leonardo Vinícius Monteiro de Assis; Douglas Brash; Carolyn Heckman; Richard McKenzie, Ben Liley and James Liley
  • Funder
  • Evidence Synthesis Programme
LATEST VERSION PUBLISHED 28 Nov 2025
https://doi.org/10.3310/nihropenres.14054.1
Research Article metrics AWAITING PEER REVIEW
The development of patient-focused diagnostic target product profiles for detection of infection and exacerbation in people with cystic fibrosis
[version 1; peer review: awaiting peer review]
Kile Green, Nicola Howe, Constance Takawira, Rebecca Holmes
Peer Reviewers Invited
  • Funders
  • NIHR HealthTech Research Centre Infrastructure Award
  • CF AMR syndicate
PUBLISHED 24 Nov 2025
https://doi.org/10.3310/nihropenres.14114.1
Study Protocol metrics AWAITING PEER REVIEW
Determining the feasibility of randomising infants, children and young people to invasive and non-invasive urine sampling techniques (FROG): Protocol for a multicentre randomised controlled feasibility trial and mixed methods perspectives’ study of RCT feasibility.
[version 1; peer review: awaiting peer review]
Paula Taylor Miller, Clíona McDowell, Ashley Agus, Lynn Murphy, Stuart Hartshorn, Srinivas Bandi, Bronagh Blackwood, Nefyn Williams, Damian Roland, Kathryn Ferris, Andrew Marshall, Alastair Sutcliffe, Mike Clarke, Kerry Woolfall, Thomas Waterfield
Peer Reviewers Invited
  • Funder
  • National Institute for Health and Care Research (NIHR) Health Technology Assessment
PUBLISHED 21 Nov 2025
https://doi.org/10.3310/nihropenres.14108.1
Systematic Review metrics AWAITING PEER REVIEW
Measures and Models of Reach in Healthcare Interventions in LMICs:  A Systematic Review
[version 1; peer review: awaiting peer review]
Takalani Tshikovhi, Robyn Curran, Jamie Murdoch, Lara Fairall
Peer Reviewers Invited
  • Funder
  • National institute for Health Research
PUBLISHED 19 Nov 2025
https://doi.org/10.3310/nihropenres.13500.2
Research Article metrics
Revised
How safe is it to plan a vaginal breech birth with OptiBreech collaborative care?: analysis of cumulative data within the OptiBreech Multiple Trials Cohort
[version 2; peer review: 2 approved, 1 approved with reservations]
Shawn Walker, Sabrina Das, Kate Stringer, Emma Spillane, Amy Meadowcroft, Siân Davies, Jacana Bresson, Alice Hodder, Jasmine Kang, The OptiBreech Collaborative
Peer Reviewers Sara Morris; Jennifer Barrowclough; Robyn Schafer
  • Funder
  • National Institute for Health and Care Research
LATEST VERSION PUBLISHED 14 Nov 2025
https://doi.org/10.3310/nihropenres.13781.4
Research Article metrics
Revised
Inclusivity of the target population in orthopaedic surgical randomised trials: a review of high impact journals
[version 4; peer review: 2 approved, 1 approved with reservations, 1 not approved]
Stephen D Brealey, Lucy Atha, Catherine Knowlson, Elizabeth Cook, Kate Hicks, Joanne Newman, Arabella Scantlebury, Joy Adamson, Caroline Fairhurst, Nick A Johnson, Joseph J Dias
Peer Reviewers Ameeta Retzer; Kim Madden; Usman Ali; Leica Claydon-Mueller
  • Funder
  • Health Technology Assessment Programme
LATEST VERSION PUBLISHED 13 Nov 2025
https://doi.org/10.3310/nihropenres.14005.2
Research Article metrics
Revised
Exploring the role of Patient and Public Involvement in Implementation Research using the Study of Implementation of Midwifery Continuity of Carer (SIMCA).
[version 2; peer review: 2 approved]
Susan Channon, Lena Choudary-Salter, Kate Davies, Tina Prendeville, Susan Barry, Heather Strange, Aimee Middlemiss, Rebecca Milton, Julia Sanders, Sara Kenyon, Aled Jones
Peer Reviewers Julie Roberts; Julie Abayomi
  • Funders
  • Research Design Service (London) Public Involvement Fund (PIF)
  • Health and Social Care Delivery Research
LATEST VERSION PUBLISHED 07 Nov 2025
https://doi.org/10.3310/nihropenres.13789.3
Review metrics
Revised
Cost-effectiveness decision modelling in social care: exploring the why, the how, and the what next
[version 3; peer review: 1 approved, 1 approved with reservations, 1 not approved]
Dacheng Huo, Sebastian Hinde, Laura Bojke, Annette Bauer, Helen Weatherly
Peer Reviewers Ian Litchfield and Melyda Melyda; Elizabeth Goodwin; Willem Kuyken
  • Funder
  • NIHR Applied Research Collaboration (ARC) Yorkshire and Humber
LATEST VERSION PUBLISHED 23 Oct 2025
https://doi.org/10.3310/nihropenres.14103.1
Research Article metrics
Empirical oral AntibioticS for possible UTI in well appearing
Young febrile infants (EASY)
[version 1; peer review: 1 not approved]
Thomas Waterfield, Ronan McMullan, Mark D Lyttle, Stuart Hartshorn, Kerry Woolfall, Sanjay Patel, Wesley Hayes, Andrew Marshall, Kathryn Ferris, Ashley Agus, Christina Campbell, Rachael Rice, Andrew Jackson, Lynn Murphy, Mike Clarke
Peer Reviewers Ghassan Ghssein
  • Funder
  • Health Technology Assessment Programme
PUBLISHED 17 Oct 2025
https://doi.org/10.3310/nihropenres.14104.1
Study Protocol metrics
Exploring the Influence of Contact with Social Workers on the Quality of Life and Wellbeing Outcomes of Adult Social Care Service Users: How, why, and for Whom? - A realist review protocol
[version 1; peer review: 1 approved with reservations]
Olamide Todowede, Janette Parr, Sarah Damery, Naila Dracup, Rachel Court, Jon Glasby, Amy Grove
Peer Reviewers Thomas Becker
  • Funder
  • National Institute for Health and Care Research
PUBLISHED 17 Oct 2025
https://doi.org/10.3310/nihropenres.13775.2
Research Article metrics
Revised
Modelling the case for cost-effectiveness of interventions to improve medication adherence in patients with difficult to control asthma
[version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Dacheng Huo, Sebastian Hinde, Harriet Smith, David Linden, Llinos Jones
Peer Reviewers Tallys Feldens; Andrea Manfrin; Carlo Lazzaro; Giovanna Culeddu
  • Funder
  • National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber
LATEST VERSION PUBLISHED 17 Oct 2025
https://doi.org/10.3310/nihropenres.13571.3
Study Protocol metrics
Revised
A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol
[version 3; peer review: 4 approved]
Laurna Bullock, Elaine Nicholls, Andrea Cherrington, Stephanie Butler-Walley, Emma M Clark, Jane Fleming, Sarah Leyland, Ida Bentley, Simon Thomas, Cynthia P Iglesias-Urrutia, David Webb, Jo Smith, Sarah Bathers, Sarah Lewis, Angela Clifford, Michele Siciliano, Joanne Protheroe, Sarah Ryan, Janet Lefroy, Nicky Dale, Ashley Hawarden, Sarah Connacher, Robert Horne, Terence W O'Neill, Christian D Mallen, Clare Jinks, Zoe Paskins
Peer Reviewers Kathlene Camp; Li Shean Toh; Alexander J. Rodríguez; Samuel Hawley
  • Funder
  • National Institute for Health and Care Research
LATEST VERSION PUBLISHED 17 Oct 2025
https://doi.org/10.3310/nihropenres.14116.1
Review metrics AWAITING PEER REVIEW
Improving Research Inclusion: learning from NIHR and Research Council funded studies in England
[version 1; peer review: awaiting peer review]
Kamaldeep Bhui, Roisin Mooney, Melissa Stepney, Kanwal Mand, Megan Kirk, Erin Lawrence, Anna Lavis
Peer Reviewers Invited
  • Funders
  • Economic and Social Research Council
  • Health Services and Delivery Research Programme
  • NIHR Oxford Biomedical Research Centre
  • UK Research and Innovation
PUBLISHED 16 Oct 2025
https://doi.org/10.3310/nihropenres.13946.1
Research Article metrics
North of England Alcohol Team (NEAT) research partnership: barriers and opportunities to deliver research into alcohol related liver disease in the north of England
[version 1; peer review: 1 approved with reservations]
Richard Parker, George Abouda, Laura Harrison, Steven Masson, Paul Richardson, Judith Cohen, Laura Goodwin, Thomas Phillips, Eileen Kaner, Amy O'Donnell, Sam Finnikin, Ian Rowe, Roya Vazirir, John Holmes
Peer Reviewers Naina Shah
  • Funder
  • NIHR
PUBLISHED 16 Oct 2025
https://doi.org/10.3310/nihropenres.14123.1
Research Article metrics AWAITING PEER REVIEW
Scoping the challenges and opportunities for a public health diversion pathway for substance use in a county district in England: a qualitative frame analysis
[version 1; peer review: awaiting peer review]
Thomas Mills, Manuela Jarrett, Jamiee Mallion, Susie Sykes, Jane Wills, Eddie Chaplin
Peer Reviewers Invited
  • Funder
  • National Institute for Health and Care Research
PUBLISHED 15 Oct 2025
https://doi.org/10.3310/nihropenres.14003.1
Research Article metrics AWAITING PEER REVIEW
Tobacco dependency treatment services for people with severe mental illness: A mixed methods rapid evaluation
[version 1; peer review: awaiting peer review]
William Phillips, Jessica Dawney, Sophie Spitters, Jennifer Newbould
Peer Reviewers Invited
  • Funder
  • Health and Social Care Delivery Research
PUBLISHED 14 Oct 2025
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